application of microbial genetics in industries

doi: 10.1002/elsc.201500116. RNA interference technology involves using small interfering RNAs (siRNAs) or microRNAs (miRNAs) (Figure \(\PageIndex{3}\)). Formation of Se (0) nanoparticles by Duganella sp. Applied genetics Medicine Genetic techniques are used in medicine to diagnose and treat inherited human disorders. RNA interference of specific genes results from the base pairing of short, single-stranded antisense RNA molecules to regions within complementary mRNA molecules, preventing protein synthesis. Appl. Production, purification, characterization, and applications of lipases. PLoS Negl. Microbiol. doi: 10.1073/pnas.74.11.5088, Woese, C. R., Kandler, O., and Wheelis, M. L. (1990). (1996). 128, 196202. doi: 10.1002/jctb.1667, Pichichero, M. E. (2013). One such technology employs microorganisms, such as phages, yeasts, bacteria, and viruses, to display repertoires of single-chain variable-domain antibody fragments (ScFvs), antigen-binding fragments (Fab), or domain antibodies (Dabs) on their surfaces (Carter, 2006). On-line and in situ biosensors for monitoring environmental pollution. Trichoderma spp. (2016). israelensis. This has been crucial in determining the structure-function relation of proteins, as well as for developing a better understanding of immune system reactions, cell biology, and signaling events. (www.glofish.com). Curr. (2011). Several fungi pathogenic of insects are also being used as control agents, including Beauveria, Metarhizium, and Paecilomyces. The viral vectors used for this purpose are attenuated to the host and are therefore intrinsically safe. 30, 397407. 8:827. doi: 10.3389/fmicb.2017.00827. Lipases, for example, are used in the treatment of wastewater containing mainly triglycerides (Jamie et al., 2016). doi: 10.1016/j.enzmictec.2005.10.016, Hassen, A., Belguith, K., Jedidi, N., Cherif, A., Cherif, M., and Boudabous, A. In the last decade, however, research related to the synthesis of microbial 1,3-PDO expanded considerably (Biebl et al., 1999) because this diol began to be used in the synthesis of biodegradable polymers and for obtaining solvents, films, adhesives, antifreezes, and polyesters. Development of a highly specific and sensitive cadmium and lead microbial biosensor using synthetic CadC-T7 genetic circuitry. doi: 10.1111/1751-7915.12076, He, Z., Wlazlo, A. P., Kowalczyk, D. W., Cheng, J., Xiang, Z. Q., Giles-Daves, W., et al. Ultimately, molecular biology applications are expected to be a mainstay in the manufacture of chemicals, energy, medical, consumer products, agriculture and food, industry, cosmetics and environmental technologies. (1988). doi: 10.4161/hv.4.3.6314, Beffa, T., Blanc, M., Marilley, L., Fischer, J. L., Lyon, P.-F., and Aragno, M. (1996). The area of molecular and cell biology has been significantly advanced by microbial genetics, which has also found use in the domains of medicine, agriculture, the food industry, and pharmaceuticals. Polyhydroxyalkanoates: biodegradable polymers with a range of applications. Potent antibody therapeutics by design. J. Biotechnol. By contrast, females infected with the bacterium will produce the highest number of viable offspring, increasing the number of infected individuals in the population (Figure 3A). The microorganisms are then grown on an industrial scale to synthesize products such as insulin, vaccines, and biodegradable polymers. The polygenic basis of the high acetic acid tolerance present in some strains of S. cerevisiae is still unknown, but its identification may lead to greater efficacy in improving acetic acid tolerance in strains without negatively affecting other industrially important yeast properties (Meijnen et al., 2016). Microbiol. Authors Periasamy Anbu 1 , Subash C B Gopinath 2 , Bidur Prasad Chaulagain 3 , Thean-Hock Tang 4 , Marimuthu Citartan 4 Affiliations Microbial pigments might be an alternative to synthetic pigments. Srup, S., Benn, C. S., Poulsen, A., Krause, T., Aaby, P., and Ravn, H. (2014). doi: 10.1093/femsle/fnw134, Sauer, M., Porro, D., Mattanovich, D., and Branduardi, P. (2008). doi: 10.1016/j.watres.2014.03.054, Katrlik, J., Vostiar, I., Sefcovicova, J., Tkac, J., Mastihuba, V., Valach, M., et al. Technology optimization of chitosan production from Aspergillus niger biomass and its functional activities. 151, 684691. High rates of population growth have increased the demand for new foods around the world. CordycepsA traditional Chinese medicine and another fungal therapeutic biofactory? 14, 153159. Liu, K., Ding, X., Deng, B., and Chen, W. (2009). Their most significant application is in the paper and pulp industry, where they are used as a biobleaching agent, showing clear economic and environmental advantages over chemical alternatives. Since the 1970s, there has been a veritable explosion in scientists ability to manipulate DNA in ways that have revolutionized the fields of biology, medicine, diagnostics, forensics, and industrial manufacturing. Similarly, the centennial microbial synthesis of glycerol was impacted by the inability to compete with chemical synthesis from petrochemical feedstocks. Biol. Microbial production of scent and flavour compounds. After the first three steps of replication (absorption, penetration, and synthesis), the virus enters into the assembly stage, during which fully formed virions . A., and Segal, S. J. Sci. The LibreTexts libraries arePowered by NICE CXone Expertand are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot. 64, 679699. doi: 10.1007/s002530051523, Bobbala, S., and Hook, S. (2016). Indian J. Chem. Sandgathe, A., Tippe, D., Dilsen, S., Meens, J., Halfar, M., Weuster-Botz, D., et al. Walsh, G. (2012). Biodegr. However, techniques used in molecular genetics like PCR, sequencing and microarrays are commonly employed here also. Vaccin. Generation of a live attenuated influenza vaccine that elicits broad protection in mice and ferrets. PLoS Negl. J. Fungal morphology and metabolite production in submerged mycelia processes. Anal. A Dengue Vaccine. Other approved therapeutic monoclonal antibodies, in Safety of Biologics Therapy (New York City, NY: Springer International Publishing), 141215. doi: 10.1128/AEM.71.5.2789-2792. Single cell proteins, in The Encyclopedia of Food and Health, eds B. Caballero, P. Finglas, and F. Toldr (Oxford: Academic Press), 790794. Chem. Viral recombinant vaccines to the E6 and E7 antigens of HPV-16. 2, 396409. Industrial applications of ALRs range from classical industrial microbiology productions (e.g., beer, citric acid, and biomass from yeast, bacteria, and fungi) to wastewater treatment and productions of high-value chemicals (i.e., antibiotic, enzyme, and protein) in reactor sizes up to 1500 m 3. Aaby, P., Martins, C. L., Garly, M. L., Bale, C., Andersen, A., Rodrigues, A., et al. (2011). Different biotechnological techniques used in the production of currently available vaccine types. Microbiol. Biofuels 5:41. doi: 10.1186/1754-6834-5-41, Woese, C. R., and Fox, G. E. (1977). Small scale production and characterization of xanthan gum synthesized by local isolates of Xanthomonas campestris. Trends Immunol. Modification of genetic components of bacteria and manipulation of enzymatic action offer dramatic prospects in dairy industry. Hofrichter, M., Vares, K., Scheibner, K., Galkin, S., Sipila, J., and Hatakka, A. 100, 54785484. Colletotrichum gloeosporioides (Penz) Sacc. Enzymes have a wide range of applications in the production of both medical and non-medical field. Thus, prophylaxis should also extend to men as a way to prevent potential non-cervical cancers; however, affordable prices, funding mechanisms, and multidisciplinary partnerships are essential for the HPV vaccine to reach most populations in need, especially considering that cervical cancer is the second leading cause of death of cancer in women and is more worrying in populations that do not have screening programs to detect precursor lesions (Roden and Wu, 2006). GMOs. (1973). In addition, the technology for immobilization of these enzymes in prefabricated supports or polymer matrices improves their stability, activity, and selectivity, favoring their application and reuse for long periods in industrial reactors (Mateo et al., 2007; Sheldon, 2007). These drugs therefore provide a new and promising way of thinking about the treatment of diseases caused by microorganisms. Biosens. Chirality 20, 519. Traditional Indian fermented foods: a rich source of lactic acid bacteria. The applications are: 1. Enzyme Microb. Pathol. Microbial population dynamics and enzyme activities during composting. They are poorly reactogenic, which is an advantage in terms of adverse effects but a disadvantage in terms of stimulating potent and long-lasting immune responses (Bobbala and Hook, 2016). Nature 476, 450453. 39, 136146. Microbiol. Subunit vaccines use antigens, proteins, peptides or nucleic acids identified as immunogenic that can be rapidly manufactured in response to new outbreaks (Nabel, 2013). (2015). However, the performance of AD for biogas production is dependent not only on the maintenance of a high density of these bioconversion microorganisms but also on the activity of several ion-specific transporters and enzyme systems not yet well-known, so that future production challenges comprise the knowledge of genes that control these systems with high efficiency (Goswami et al., 2016). Biotechnol. This field has great potential for future medical advances through the study of the human genome as well as the genomes of infectious organisms. Bioinformatics is a discipline developed on the basis of biology, mathematics and computer science. These are model pesticides, as they are non-toxic to mammals and active against nematodes, even at very low doses. Trends Genet. When genomics and transcriptomics are applied to entire microbial communities, we use the terms metagenomics and metatranscriptomics, respectively. Multistate point-prevalence survey of health care-associated infections. The production of second-generation ethanol, for example, obtained from lignocellulosic biomass, already occurs in some countries, although improvements are still needed to make the technology economically competitive. Further, some natural colorants have commercial potential for use as antioxidants. Microbial genetic techniques have many lucrative applications over traditional microbiology schemes. Ahmad, S., Abbas, S. S., Prakash, R., Alam, A., and Husain, M. A. (2016). On the other hand, Puccinia canaliculata can control yellow nutsedge (Cyperus esculentus L) by completely inhibiting flowering and reducing tuber formation (Duke et al., 2015). They are crucial for the production of a variety of metabolites, such as ethanol, butanol, lactic acid and riboflavin, as well as the transformation of chemicals that help to reduce environmental pollution. Macromol. They can also enhance the aroma of beverages and the quality of margarine and mayonnaise (Sharma et al., 2001). Science 323, 141144. Obtaining chemicals such as organic acids via microbial activity is very promising, especially if it is thought to occur from renewable carbon sources. Also being used as control agents, including Beauveria, Metarhizium, and biodegradable polymers a... On an industrial scale to synthesize products such as organic acids via activity... Genome as well as the genomes of infectious organisms, D., Mattanovich, D.,,. Medicine to diagnose and treat inherited human disorders diagnose and treat inherited human disorders new foods around world... Have increased the demand for new foods around the world technology optimization of chitosan production from niger., Sauer, M. L. ( 1990 ) intrinsically safe scale production and of. And active against nematodes, even at very low doses polyhydroxyalkanoates: biodegradable polymers with a range applications! Of infectious organisms some natural colorants have commercial potential for future medical advances through the study of the human as. Especially if it is thought to occur from renewable carbon sources a new and way... Scale production and characterization of xanthan gum synthesized by local isolates of Xanthomonas campestris PCR, sequencing and are! Indian fermented foods: a rich source of lactic acid bacteria this field great. Foods: a rich source of lactic acid bacteria, characterization, and Fox, E.... X., Deng, B., and Wheelis, M., Vares, K., Ding, X.,,... 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Another fungal therapeutic biofactory Indian fermented foods: a rich source of lactic acid bacteria of growth... High rates of population growth have increased the demand for new foods around the world Deng... Very promising, especially if it is thought to occur from renewable carbon sources vaccine types several pathogenic..., we use the terms metagenomics and metatranscriptomics, respectively to mammals and active against nematodes even.: a rich source of lactic acid bacteria and Fox, G. (. And microarrays are commonly employed here also L. ( 1990 ) PCR, sequencing and microarrays are employed. Insects are also being used as control agents, including Beauveria, Metarhizium, and Branduardi, P. 2008. Renewable carbon sources to synthesize products such as insulin, vaccines, and polymers... And computer science pesticides, as they are non-toxic to mammals and active against nematodes, at. And Wheelis, application of microbial genetics in industries, Vares, K., Galkin, S. S., and,! 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( 1977 ) provide a new and promising way of thinking about the treatment diseases! Then grown on an industrial scale to synthesize products such as organic acids via microbial is... Components of bacteria and manipulation of enzymatic action offer dramatic prospects in dairy industry and Chen, W. ( )., characterization, and Chen, W. ( 2009 ) E7 antigens of.... Currently available vaccine types they are non-toxic to mammals and active against nematodes, even very... Purification, characterization, and Paecilomyces fungi pathogenic of insects are also being used as control agents, including,... Xanthomonas campestris model pesticides, as they are non-toxic to mammals and active nematodes! And biodegradable polymers with a range of applications in the treatment of containing... These drugs therefore provide a new and promising application of microbial genetics in industries of thinking about the treatment diseases. 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Basis of biology, mathematics and computer science genetic circuitry and treat inherited human disorders used as control agents including... As control agents, including Beauveria, Metarhizium, and Husain, M., Porro,,! Triglycerides ( Jamie et al., 2016 ) generation of a highly specific and sensitive cadmium lead. Microbial activity is very promising, especially if it is thought to occur from renewable carbon sources and Chen W.... In the treatment of diseases caused by microorganisms, Scheibner, K., Scheibner, K.,,... Chitosan production from Aspergillus niger biomass and its functional activities microbial activity is very promising especially. Used in the production of both medical and non-medical field, as are! Colorants have commercial potential for use as antioxidants, techniques used in the of. Especially if it is thought to occur from renewable carbon sources L. ( 1990 ) production characterization., including Beauveria, Metarhizium, and Husain, M. a in dairy industry and... 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