1980. Foster City, CA: Chemical Toxicology Institute.
Although genotoxicity test data suggest that methylmercury is capable of producing chromosomal and nuclear damage, there are also nonpositive genotoxicity data.
LD50 e d de d n e LD50 rat oral mg/kg.
The elimination of mercury from blood showed little correspondence to age during the 30 days duration. Please enable it to take advantage of the complete set of features! [, Dalla Corte CL, Wagner C, Sudati JH, Comparsi B, Leite GO, Busanello A, Soares FA, Aschner M, Rocha JB. trailer
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Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet.
[, Ziemba SE, Menard SL, McCabe MJ Jr, Rosenspire AJ: T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury. 0000004166 00000 n
1978 Sep;20(3):353-60. doi: 10.1007/BF01683532. Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition (, Ingested methylmercury is readily and completely absorbed by the gastrointestinal tract. Toxicology of Metals. The onset of neurological symptoms after receiving 25 mg Hg/kg of methylmercury chloride occurred between 8 to 15 days post dosing in the surviving rats. Air Quality Guidelines. Bull Environ Contam Toxicol. FASEB J. [. 1976 Mar;5(3):337-49. doi: 10.1016/0300-483x(76)90052-4.
PLoS One. These are metal alkyls, where the alkyl group is attached to a transition metal atom.
"The effects of methyl mercury binding to microtubules". /Producer(Sub Systems, Inc.)/CreationDate(D:20200226193604+05'00')/ModDate(D:20200226193604+05'00')/Creator(Sub Systems, Inc.)
Biomed Res Int. Epub 2013 Aug 13. "Effects of diphenyl diselenide on methylmercury toxicity in rats.".
[, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Toxicol Sci.
Last Updated 8 March 2009. The methylmercuric-cysteinyl complex is recognized by amino acid transporting proteins in the body as methionine, another essential amino acid.
| 2018 Aug 30;13(8):e0203335.
The LD50values for various rodent species range from 21 to 57.6 mg/kg (RTECS, 1986). Toxicol Appl Pharmacol. [, Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Neurol. eCollection 2018. Uses/Sources: Methylmercury is a pollutant producted by the burning of fossil fuels and wastes containing inorganic mercury. Fetal methylmercury poisoning: Relationship between concentration in a single strand of maternal hair and child effects.
Minimal Risk Levels (MRLs) for Hazardous Substances. 2013;2013:983821. doi: 10.1155/2013/983821.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Metallothionein.
It potently affects the release of neurotransmitter from presynaptic nerve terminals. [, Clifton JC 2nd: Mercury exposure and public health. -, Bull Environ Contam Toxicol.
It is a bioaccumulative environmental toxicant.
Nucleic Acids Res. Get the latest research from NIH: https://www.nih.gov/coronavirus.
Baselt RC (2000). Disposition of Toxic Drugs and Chemicals in Man, 5th ed. It is particularily hazardous due to its ability to bioaccumulate in the environment, particularily in aquatic systems. Toxicol Appl Pharmacol. 0000000727 00000 n
As the age increases, the LD50 decreases, i.e. The permeability of erythrocyte membrane to mercury might play an important role in the age factors on the suceptibility of methylmercury intoxication. J Am Vet Med Assoc. %����
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Predicted LC-MS/MS Spectrum - 10V, Positive, splash10-014i-0090000000-fb24991f3b85643f7524, Predicted LC-MS/MS Spectrum - 20V, Positive, splash10-014i-0090000000-696860249a4158e95a97, Predicted LC-MS/MS Spectrum - 40V, Positive, splash10-014i-1090000000-14fbd38252e8c43622f5, Methylmercury is neurotoxic. Methylmercury alters calcium ion concentrations by at least two mechanisms.
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Last Updated 20 December 2008. USA.gov. Organic mercury complexes with free cysteine and the cysteine and sulfhydryl groups on proteins such as haemoglobin. LD50: 58 mg/kg (Oral, Rat) LD50: 14 mg/kg (Intraperitoneal, Mouse) Lethal Dose: 100 mg/kg for an adult human (average for organic mercurials). NIH LD50 of methylmercury chloride has been shown to be dependent on the ages of the rats.
X���`I�%&/m�{J�J��t��`$ؐ@������iG#)�*��eVe]f@�흼��{���{���;�N'���?\fdl��J�ɞ!���?~|? Biol Cell. ?���t#_n|��z%�4�n����#(!���:Ȇl�M�D���?ܽ��? 1994 Jun;8(9):622-9. 0000001509 00000 n
| Comparative study of uptake and tissue distribution of methylmercury in female rats by inhalation and oral routes of administration. 0000003248 00000 n
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Treatment of methylmercury poisoning in the rat with sodium 2,3-dimercaptopropane-i-sulfonate: influence of dose and mode of administration. Teratogenic effects also were worse for the combined mercury plus selenium treatment; deformities were recorded in 6.1% of the embryos of controls, 16.4% for those fed methylmercury chloride, 36.2% for those fed , and 73.4%. [, Raghu KG, Kodi RB, Vijayalakshmi K, Bapu C, Sood PP.
belongs to the class of organic compounds known as transition metal alkyls. A second phase developing over 1-3 days is characterized by stomatitis (lesions of the mouth parts), membranous colitis and kidney damage (tubular nephritis).
-. [, Wikipedia. 0000030689 00000 n
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