For a complete listing, see the Dosage Form, Composition and Packaging section of the Prescribing Information. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. contamination. Renal clearance of unchanged peramivir accounts for approximately 90% of total clearance. In vitro binding of peramivir to human plasma proteins is less than 30%. Peramivir is an antiviral drug with activity against influenza virus [see Microbiology (12.4)]. Phase III randomized, double-blind study comparing single-dose intravenous peramivir with oral oseltamivir in patients with seasonal influenza virus infection. The following adverse reactions are discussed in other sections of the labeling: Serious skin and hypersensitivity reactions [see Warnings and Precautions (5.1)], Neuropsychiatric Events [see Warnings and Precautions (5.2)], Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed, in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug. 2015; 90:97-108. http://www.ncbi.nlm.nih.gov/pubmed/25771542?dopt=AbstractPlus, 563. Oseltamivir-Resistant Influenza A(H1N1)pdm09 Viruses, United States, 2013-14. tell your doctor and pharmacist if you are allergic to peramivir injection, any other medications, or any of the ingredients in peramivir injection.
E��Z;�ŋ�| t'�/>���|��o�Yt{��ק �y��Τt���x��3M��x��7_;��v�Y����$����T ^;��߽��%�v`�������櫗}�L��ԩU�t�bL�?`L-C�`���C�g��d�|ɋ��y��&3���칾����=�5{����������WV��Wwo����O/_�p���]�[��\��;���a�>v��GR�ȿ�zF� �q�p���A�T�Y�o4o���,� �!�o���K�N�P�0Nqrڐ~�A��}�ƬaE├���c��H ��V�b�h���8��M�n�B0Ǻ�=׃�%EN�W�v��1�W��l�ԊW N:m�(��]B,;�Ť��1�b�ᐑwTb���R�c.���oM���(�c�(!n�IB�u���ӳ�Dt��i�ģ�ڵ�ynxN&�B.����6Z2�K�۶�L� Peramivir was also administered by continuous intravenous infusion to rats at daily doses of 50, 400, and 1000 mg/kg/day on gestational days 6-17. Virostatikum, 116. 2018; 93:133-41. http://www.ncbi.nlm.nih.gov/pubmed/29569429?dopt=AbstractPlus, HID. Do not use if seal over bottle opening is broken or missing. WHO guidelines for pharmacological management of pandemic influenza A (H1N1) 2009 and other influenza viruses. inhibitor of P-glycoprotein mediated transport. Update: Swine influenza A (H1N1) infections–California and Texas, April 2009. Update: influenza activity - United States, August 30, 2009-March 27, 2010, and composition of the 2010-11 influenza vaccine. AHFS® Patient Medication Informationâ¢. treated with RAPIVAB was proteinuria by dipstick analysis (3% versus 0% for oseltamivir). MMWR Morb Mortal Wkly Rep. 2009; 58:435-7. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2018-19 Influenza Season. RAPIVAB is cleared by renal excretion and can be cleared by hemodialysis. (1), Administer RAPIVAB as a single dose within 2 days of onset of influenza symptoms (2.1), Administer RAPIVAB by intravenous infusion for a minimum of 15 minutes (2.1), Adults and adolescents (13 years and older), Pediatric patients (2 to 12 years of age), Hemodialysis: Administer after dialysis (2.2), RAPIVAB must be diluted prior to administration (2.3), See the Full Prescribing Information for drug compatibility information (2.4), Injection: 200 mg in 20 mL (10 mg/mL) in a single-use vial (3), Patients with known serious hypersensitivity or anaphylaxis to peramivir or any component of RAPIVAB (4), Cases of anaphylaxis and serious skin/hypersensitivity reactions such as Stevens-Johnson syndrome and erythema, multiforme have occurred with RAPIVAB.
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