the differences depends on the person who uses this terms :). A polymorphism is a variation that exists in or becomes fixated within a population, e.g. hi there all...Its an old question but one that doesnt seem to find a consensus in terms of an answer...i would like to hear what the true definition of mutation Vs polymorphism is.I need verfication on MY understanding...and if im wrong could i be corrected.Thankyou.Yes both are changes but is more truthful to explain it as a mutation: is induced from outside the cell: by an exogenous factor, is inheritable and does not necessarily harmful to the host. Even variants that are quite often can cause the clinical phenotype (thing of lactose intolerance). I know that there are different types of SNPs (https://en.wikipedia.org/wiki/Single-nucleotide_po... Use of this site constitutes acceptance of our, Traffic: 2056 users visited in the last hour, modified 2.1 years ago What Is The Difference Between A Snp And An Entry In A Mutation Database? ?Thankyou for your help143. A rule of thumb that is sometimes used is to classify genetic variants that occur below 1% allele frequency as mutations rather than polymorphisms.
So, mutations are events that generate polymorphisms.But can recombination, which can generate new alleles of a gene and therefore polymorphism of that gene, be considered as a mutational event? I am working on breast cancer and try to detect somatic point mutation in FFPE samples. A mutation is more like an event. Insertion-deletions below 50bp are "small indels" which can be "indel variant", "indel mutation" or "indel polymorphism". Thank you for participating in the discussion. by a simple error in duplication, cell-division, strand-break, radiation, toxins, etc. RT has no proofreading activity so there's a lot of random "mutations" in there.The thing is that due to the large variety in its genome, there's been made up a classification into subtypes (it's HIV-1 group M we're talking about). I am returning to bioinformatics after a long absence and the landscape has certainly chan... 1. what is the difference between Alzheimer's disease, Parkinson disease, Huntington disease and ... What is the algorithm based difference between Mutect2 and HaplotypeCaller in detecting somatic a... Dear all, Mutations don't always have a strong negative effect, and such mutations (or changes) in DNA sequence can remain in the population. Here are my questions that I hope you'd be able to help to elucidate: In popgen, a mutation is described as a one time single event, while a polymorphism is a mutation that was able to increase in frequency within the population..More precisely, if the frequency of appearance of the "variant" is higher that neutral equilibrium population mutation rate, it is a polymorphism.
BDNF Missense Mutation / Natural Variants, Difference between somatic mutations and somatic hyper mutation, Detecting Frameshift Between Splice Variants Of A Gene. through evolution the cell changes to conform to the changing environment to survive...(after all the basic function of a cell is to use all its various pathways and mechanism to surivive and thereby maintaining its function within the host. A polymorphism refers to a variation in genomes in one species. Differences between gene polymorphism and mutation. Hi there allits an old question, but one that does not seem to have a consensus in terms of a precise definition. to the given variation/locus for which a prevalence can be assigned. Nonsynonymous mutations have a much greater effect on an individual than a synonymous mutation. Nonsynonymous Mutations . Mutations are any changes made in the sequence of DNA. Now, for certain mutations it is known that they only are "induced" due to therapy in certain subtypes but are omnipresent in other subtypes (and are therefor within this subtype calles "polymorphisms"). and alzheimer. The explanation I've been given is that a mutation causes disease whereas a polymorphism does not. Policy. THankyouYes both are changes but is it more truthful to explain it as: a mutation: is induced from outside the cell: by an exogenous factor, is inheritable and will not necessarily be harmful to the host. Therefore, the main difference between SNP and mutation is their frequency and influence. As you know, there are some antiretroviral compounds used for treatment of HIV-infected people. Without going into detail, these virus in these individuals will get mutations that will cause the virus to be less susceptible to certain drugs (the cause for therapy failure).
I don't think the source of the genomic change (so exogenous or endogenous) has something to do with it.Hope it helpsDavid, A polymorphism is a mutation that has been proven to have a prevelance above a certain % in a given population. For example, certainly in the circles I move in academically, "variant" would probably be the vague term and you wouldn't get very far using it. If its an INDEL, it gets a little more complicated depending on the type of mutation specifically. Instead just say "variant".
polymorphism). type of mutation specifically.
Therefore, at least two genotypes exist wrt. References: 1. I agree with the definition of mutant, with the exception of the clinical term.
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